Introduction to Biomedical Engineering

John Enderle 
Susan Blanchard
Joseph Bronzino

Second Edition
Elsevier Academic Press
© 2005


First Edition
Academic Press, Inc.
San Diego, California, USA
© 2000

The purpose of the second edition remains the same as the first edition, that is, to serve as an introduction to and overview of the field of biomedical engineering. Many chapters have undergone major revision from the previous edition with new end of chapter problems added. Some chapters were combined and some chapters were eliminated completely, with several new chapters added to reflect changes in the field.

Over the past fifty years, as the discipline of biomedical engineering has evolved, it has become clear that it is a diverse, seemingly all-encompassing field that includes such areas as bioelectric phenomena, bioinformatics, biomaterials, biomechanics, bioinstrumentation, biosensors, biosignal processing, biotechnology, computational biology and complexity, genomics, medical imaging, optics and lasers, radiation imaging, rehabilitation engineering, and tissue engineering. Although it is not possible to cover all of the biomedical engineering domains in this textbook, we have made an effort to focus on most of the major fields of activity in which biomedical engineers are engaged, including morals and ethics.

The text is written primarily for engineering students who have completed differential equations and a basic course in statics. Students in their sophomore year or junior year should be adequately prepared for this textbook. Students in the biological sciences, including those in the fields of medicine and nursing can also read and understand this material if they have the appropriate mathematical background.

Although we do attempt to be fairly rigorous with our discussions and proofs, our ultimate aim is to help students grasp the nature of biomedical engineering. Therefore, we have compromised when necessary and have occasionally used less rigorous mathematics in order to be more understandable. A liberal use of illustrative examples amplifies concepts and develops problem-solving skills. Throughout the text, MATLAB® (a matrix equation solver) and SIMULINK® (an extension to MATLAB® for simulating dynamic systems) are used as computer tools to assist with problem solving. The Appendix provides the necessary background to use MATLAB® and SIMULINK®. MATLAB® and SIMULINK® are available from:

The Mathworks, Inc.
24 Prime Park Way
Natick, Massachusetts 01760
Phone: (508) 647-7000

Chapters are written to provide some historical perspective of the major developments in a specific biomedical engineering domain as well as the fundamental principles that underlie biomedical engineering design, analysis, and modeling procedures in that domain. In addition, examples of some of the problems encountered, as well as the techniques used to solve them, are provided. Selected problems, ranging from simple to difficult, are presented at the end of each chapter in the same general order as covered in the text.

The material in this textbook has been designed for a one-semester, two-semester, or three-quarter sequence depending on the needs and interests of the instructor. Chapter 1 provides necessary background to understand the history and appreciate the field of biomedical engineering. Chapter 2 presents the vitally important chapter on biomedically based morals and ethics. Basic anatomy and physiology is provided in Chapter 3. Chapters 4-10 provide the basic core biomedical engineering areas: biomechanics, rehabilitation, biomaterials, tissue engineering, bioinstrumentation, biosensors and biosignal processing. To assist instructors plan the sequence of material they may wish to emphasize, it is suggested that the chapters on bioinstrumentation, biosensors and biosignal processing should be covered together as they are interdependent on each other. The remainder of the textbook presents material on biomedical technology (Chapters 12-17).

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